Royal Air Force Typhoon FGR4s have operated alongside French warplanes in a combined operation against an subterranean weapons facility in Syrian territory used by the IS group, per a report from the British defence ministry.
The location, located using reconnaissance, was assessed as containing munitions and bombs, the statement said, and was located in mountainous terrain just to the north of Palmyra in Syria's central region.
"Our aircraft utilized laser-guided Paveway IV weapons to target a several approach shafts providing entry to the depot... initial indications are that the objective was successfully hit," the MoD said.
There was no indication of any civilian impact in the strike conducted Saturday night and each participating jet made a safe return, the MoD added.
The Typhoon FGR4s were backed up by a Voyager aerial refuelling aircraft.
IS - alternatively referred to as ISIS - established jihadist rule over large swathes of both Syria and Iraq until 2019.
"This strike demonstrates our UK leadership, and resolve to stand shoulder to shoulder with allied nations, to stamp out any re-emergence of the terrorist group and their violent and radical beliefs in the area," UK Defence Secretary John Healey remarked.
RAF aircraft have conducted surveillance missions over Syrian airspace to "forestall any efforts to regroup" of Islamic State after its routing at the Baghuz confrontation in the year 2019, the ministry said.
"I must thank all the members of the UK armed forces who took part in this strike for their professionalism and their courage," he added. "Including them were numerous UK service members on duty over the holidays. This action, to take out dangerous terrorists who endanger our way of life, shows how UK forces are prepared to act, all year round, keeping Britain secure at home and powerful internationally."
Last December, the American forces executed what it called a "large-scale strike" against Daesh sites in the country, subsequent to an assault killed two American soldiers and a civilian interpreter in Palmyra.
The United Nations reports Islamic State still maintains between 5,000 and 7,000 combatants in both countries.